“Epigenetic changes can be reversible, offering hope for interventions and therapies”.
-The Epigenetics Revolution
The later half of the 21st century has seen the dire consequences of how nutrition, drugs and environment as well as genetics inter-connectedly has a cause-and-effect relationship. This discovery has not just revolutionised the way we see our research potential and capacity but also its development in treating diseases in the field of medicine itself. The years 2020, 2021, 2022, 2023, and up and coming 2024 have resulted in extensive research in this area.
According to Merriam-Webster, Epigenetics is the study of heritable changes in gene function that do not involve changes in DNA sequence. Epigenetics is by many, today understood as the reprogramming or alteration of DNA reconfiguration of underlying sequence. We have moved to newer and more advanced technologies enabling us to discover more and more everyday. There are two types of epigenetic disorders that are widely differentiated: imprinting disorders (IDs) and the Mendelian disorders of the epigenetic machinery (MDEMs).
IDs are a diverse group of congenital disorders that affect genome imprinted chromosomal regions and genes that further impact growth, development, metabolism, and common molecular disturbances. MDEMs on the other hand, are genetic disorders that disrupt writers, erasers, readers, and remodellers. The writers, erasers, and readers are all involved in creating and somewhat inventing the epigenetic changes appearing on the DNA sequence.
The role of each as such is as follows, writers-initiate by introducing chemical modifications on DNA and histones, readers-domain proteins that specialise in interpreting these modifications, erasers-enzymes are well equipped to remove these chemical alterations made. Acetylation and methylation processes influence the epigenetic indicators.
The following diseases are associated with epigenetic markers: cancer, inherited X-linked mental retardation and intellectual disabilities, ageing, diabetes mellitus type 2, obesity, smoking, vaping, asthma, autism, changes in pregnancy including chronic UTIs. There has also been light shed on the changes in the body caused due to air pollution as well as ultra-processed foods causing cancer and affecting fertility as well. Some drugs can accelerate or decelerate genetic mutations in a way that is unimaginable!
Nivea Vaz
Manipal College of Medical. Sciences, Pokhara







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